HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-1-methylpiperidine → HCID 57955660, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-1-methylpiperidine | HCID 2737531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 67117824 | HCID 67117824 | — |
| Product | HCID 57955660 | HCID 57955660 | — |
Reaction Steps
The title compound was synthesized from 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-2-methoxybenzoic acid as described in the general procedure for amide bond synthesis using HATU and 1-methylpiperidin-4-amine. The final compound was purified by reverse phase HPLC. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.48-2.22 (m, 14H) 2.66-2.88 (m, 2H) 3.05 (m, 2H) 3.33 (s, 3H) 3.46 (d, J=11 Hz, 2H) 3.86 (s, 3H) 4.05 (t, J=14 Hz, 3H) 4.81 (m, 1H) 7.49 (m, 2H) 7.64 (m, 1H) 7.93 (d, J=7 Hz, 1H) 8.28 (s, 1H) 9.69 (s, 1H). [M+H] calc'd for C27H35F2N7O3, 544. found 544.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026234B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-9061a3126bed4da09117acfb3a24d603 |
| Source note | uspto-grants-2011_09 |