3-(4-Methylpiperazin-1-yl)aniline → HCID 57955568, compound

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Reaction Steps

The title compound was prepared in a manner analogous to compound 149 from 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid and 3-(4-methylpiperazin-1-yl)aniline with yield 35 mg (28%). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.43-1.72 (m, 6H) 1.98 (br. s., 2H) 2.22 (s, 2H) 2.35-2.50 (m, 4H) 2.97-3.23 (m, 4H) 3.98 (s, 3H) 4.06 (t, J=12 Hz, 2H) 4.79 (m, 1H) 6.55-6.79 (m, 1H) 7.12-7.26 (m, 2H) 7.40 (s, 1H) 7.52-7.72 (m, 2H) 8.03 (s, 1H) 8.28 (s, 1H) 8.35 (d, J=8.34 Hz, 1H) 9.94 (s, 1H). [M+H] calc'd for C32H38F2N8O3, 621. found 621.

Provenance & Evidence