4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-2-fluoro-5-methoxybenzoic acid → HCID 57955625, compound

HRID 914233Notes

Reaction equation

HRID 914233 reaction equation
[CH:1]1([N:6]2[CH2:12][C:11]([F:14])([F:13])[C:10](=[O:15])[N:9]([CH3:16])[C:8]3[CH:17]=[N:18][C:19]([NH:21][C:22]4[C:30]([O:31][CH3:32])=[CH:29][C:25]([C:26]([OH:28])=O)=[C:24]([F:33])[CH:23]=4)=[N:20][C:7]2=3)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[CH3:35][N:36]1[CH2:41][CH2:40][N:39]([CH2:42][C:43]2[CH:49]=[CH:48][C:46]([NH2:47])=[CH:45][CH:44]=2)[CH2:38][CH2:37]1>>[CH:1]1([N:6]2[CH2:12][C:11]([F:14])([F:13])[C:10](=[O:15])[N:9]([CH3:16])[C:8]3[CH:17]=[N:18][C:19]([NH:21][C:22]4[C:30]([O:31][CH3:32])=[CH:29][C:25]([C:26]([NH:47][C:46]5[CH:45]=[CH:44][C:43]([CH2:42][N:39]6[CH2:38][CH2:37][N:36]([CH3:35])[CH2:41][CH2:40]6)=[CH:49][CH:48]=5)=[O:28])=[C:24]([F:33])[CH:23]=4)=[N:20][C:7]2=3)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 252536794-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-2-fluoro-5-methoxybenzoic acidHCID 67117850HCID 67117850, compound

Product 1

HCID 57955625HCID 57955625, compound

Procedure

The title compound was prepared in a manner analogous to compound 149 from 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-2-fluoro-5-methoxybenzoic acid and 4-((4-methylpiperazin-1-yl)methyl)aniline hydrochloride with yield 48 mg (37%). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.62 (br. s., 4H) 1.73 (br. s., 2H) 1.98 (m, 2H) 2.14 (s, 3H) 2.17-2.45 (m, 8H) 3.40 (s, 2H) 3.94 (s, 3H) 4.09 (t, J=12 Hz, 2H) 4.84 (t, J=8.08 Hz, 1H) 7.16-7.37 (m, 3H) 7.66 (d, J=8.34 Hz, 2H) 8.10 (s, 1H) 8.19-8.39 (m, 2H) 10.13 (s, 1H). [M+H] calc'd for C33H39F3N8O3, 653. found 653.

Sources & evidence

ORD record
ord-886a4d8f1f0e4736bcb27d5249a4d3b1
Source dataset
uspto-grants-2011_09
Patent number
US08026234B2

Reaction notes

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