反应详情

2-(5-Bromo-4-oxopentyl)-isoindoline-1,3-dione (17.8 g) synthesized using 1-chloro-4-oxopentane and potassium phthalimide as starting materials and in reference to non-patent reference [Pharmazie, 47, 86 (1992)] and the like and ammonium dithiocarbamate (6.96 g) were suspended in ethanol (250 mL), and the suspension was refluxed for 6 hr. The precipitated crystals were collected by filtration and washed with ethanol to give the title compound (10.1 g) as white crystals.

1. temperaturethe suspension was refluxed for 6 hr
2. filtrationThe precipitated crystals were collected by filtration
3. washwashed with ethanol