Hydrazine hydrate (1:1) → HCID 59759144, compound

Participants

Reaction Steps

2-[(4-{2-[(4′-Fluoro-3-nitrobiphenyl-4-yl)oxy]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester (2.0 g) obtained in Example 97-2 was dissolved in methanol (20 mL), a catalytic amount of iron chloride (III) (62 mg), activated carbon (1.0 g) and hydrazine monohydrate (580 mg) were successively added, and the mixture was heated under reflux for 3 hr. The mixture was filtered through celite, methanol was evaporated under reduced pressure, and the residue was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (1.5 g).

Provenance & Evidence