Trifluoroacetic acid → HCID 67397937, Verbindung

HRID 914354Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 914354
C([O:5][C:6](=[O:26])[C:7]([S:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][CH2:17][NH:18][C:19]2[N:24]=[CH:23][C:22](Br)=[CH:21][N:20]=2)[N:15]=1)([CH3:9])[CH3:8])(C)(C)C.[C:27]1(B(O)O)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39]>ClCCl>[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39].[CH3:9][C:7]([S:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][CH2:17][NH:18][C:19]2[N:20]=[CH:21][C:22]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:23][N:24]=2)[N:15]=1)([CH3:8])[C:6]([OH:5])=[O:26]

Komponenten

5

Edukt 3

HCID 6422Trifluoroacetic acidHCID 66827Phenylboronic AcidHCID 597588042-[(4-{2-[(5-Bromopyrimidin-2-yl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester

Produkt 1

HCID 67397937HCID 67397937, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The compound obtained using 2-[(4-{2-[(5-bromopyrimidin-2-yl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester synthesized in Example 162-1 and phenylboronic acid as starting materials and by an operation similar to that of Example 162-2 was treated with dichloromethane and trifluoroacetic acid, and the mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated under reduced pressure, and the obtained solid was triturated and washed with hexane-ethyl acetate to give the title compound as a white solid.

Aufarbeitung

  1. customThe compound obtained
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customthe obtained solid was triturated
  4. washwashed with hexane-ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-ec967db161134fe7967b9f0598f206ed
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08026370B2

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