Hydrogen chloride-ethyl acetate → HCID 178428493, compound

HRID 914381Notes

Reaction equation

HRID 914381 reaction equation
C([O:5][C:6](=[O:31])[C:7]([CH3:30])([S:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][CH2:16][NH:17][CH2:18][C:19]2[CH:20]=[N:21][N:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH:23]=2)[N:14]=1)[CH3:8])(C)(C)C.[ClH:32].C(O[CH2:37][CH3:38])(=O)C>C(OCC)C>[ClH:32].[CH3:8][C:7]([S:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][CH2:16][N:17]([C:20]2[NH:21][N:22]=[C:37]([CH3:38])[CH:19]=2)[CH2:18][C:19]2[CH:20]=[N:21][N:22]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH:23]=2)[N:14]=1)([CH3:30])[C:6]([OH:5])=[O:31]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 597588602-methyl-2-{[4-(2-{[(1-phenyl-1H-pyrazol-4-yl)methyl]amino}ethyl)-1,3-thiazol-2-yl]thio}propionic acid tert-butyl ester

Product 1

HCID 178428493HCID 178428493, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A compound obtained using 2-methyl-2-{[4-(2-{[(1-phenyl-1H-pyrazol-4-yl)methyl]amino}ethyl)-1,3-thiazol-2-yl]thio}propionic acid tert-butyl ester synthesized in Example 451-2, and by an operation similar to that of Example 446 was dissolved in diethyl ether, and reacted with 4 mol/L hydrochloric acid-ethyl acetate to give the title compound.

Workup

  1. customA compound obtained

Sources & evidence

ORD record
ord-d06c45817ce14eadb9610be1de0f4518
Source dataset
uspto-grants-2011_09
Patent number
US08026370B2

Reaction notes

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