反应详情

温度

0 °C

To a solution of {2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}acetic acid (160 g) obtained in Example 3 in dichloromethane (500 mL) were added 9H-fluorene-9-ylmethanol (98 g) and 4-dimethylaminopyridine (3.1 g), diisopropylcarbodiimide (78 ml) was added dropwise under ice-cooling, and the mixture was stirred at 0° C. for 1 hr and further stirred at room temperature for 2 hr. The precipitate was removed from the reaction mixture by filtration, and the filtrate was concentrated under reduced pressure and purified by silica gel chromatography (elution solvent; hexane:ethyl acetate=4:1) to give the title compound (260 g) as a yellow oil.

1. additionwas added dropwise under ice-
2. temperaturecooling
3. stirringfurther stirred at room temperature for 2 hr
4. customThe precipitate was removed from the reaction mixture by filtration
5. concentrationthe filtrate was concentrated under reduced pressure
6. custompurified by silica gel chromatography (elution solvent; hexane:ethyl acetate=4:1)