HCID 67397745, compound → HCID 67399150, compound

Participants

Reaction Steps

To a suspension of 2-({4-[2-(heptylamino)-2-oxoethyl]-1,3-thiazol-2-yl}thio)-2-methylpropionic acid resin (5.2 g) synthesized in Example 461-5 in tetrahydrofuran (20 mL) was added 1 mol/L borane-tetrahydrofuran complex (18 ml), and the mixture was stirred at room temperature for 30 min, and at 50° C. for 16.5 hr. The resin was collected by filtration from the mixture, washed three times each with tetrahydrofuran and methanol, and vacuum dried to give the title pale-yellow resin (4.0 g).

Provenance & Evidence