Dichloromethane → HCID 67399604, compound

Participants

Reaction Steps

2-Methyl-2-({4-[2-({3-methyl-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}amino)ethyl]-1,3-thiazol-2-yl}thio)propionic acid tert-butyl ester (690 mg) synthesized in Example 253-1 was dissolved in dichloromethane (4 mL), trifluoroacetic acid (4 mL) was added, and the mixture was stirred at room temperature for 20 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (elution solvent; hexane:ethyl acetate=2:1 to 1:1). The obtained compound was dissolved in diethyl ether (4 mL), 4 mol/L hydrochloric acid-ethyl acetate (0.5 mL) was added, and the mixture was stirred at room temperature for 1 hr. The precipitated solid was collected by filtration to give the title compound (461 mg) as a white solid.

Provenance & Evidence