HCID 59759337, compound → HCID 67395902, compound

Participants

Reaction Steps

2-[(4-{2-[(5-Carbamoyl-3-chloropyridin-2-yl)(heptyl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester (300 mg) obtained in Example 281-2 was dissolved in trifluoroacetic acid (5 mL), and the mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated under reduced pressure, dissolved in ether, and 4N hydrochloric acid/ethyl acetate was added. The precipitated crystals were collected by filtration to give the title compound (243 mg) as white crystals.

Provenance & Evidence