Triethylamine → HCID 67398468, compound

Participants

Reaction Steps

2-[(4-{2-[(5-Carbamoyl-3-chloropyridin-2-yl)(heptyl)amino)ethyl)-1,3-thiazol-2-yl)thio)-2-methylpropionic acid tert-butyl ester (0.85 g) synthesized in Example 281-2 was dissolved in dichloromethane (10 mL), triethylamine (0.26 mL), trifluoroacetic acid anhydride (0.24 mL) was added, and the mixture was stirred at room temperature for 3 hr. The reaction mixture was washed with water, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel chromatography (elution solvent; hexane:ethyl acetate=9:1) to give the title compound (0.37 g).

Provenance & Evidence