Trifluoroacetic acid → HCID 67399512, compound

Participants

Reaction Steps

2-[(4-{2-[(3-Chloro-5-cyanopyridin-2-yl)(heptyl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester (0.37 g) obtained in Example 282-1 was dissolved in dichloromethane (10 mL), trifluoroacetic acid (2 mL) was added, and the mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated under reduced pressure, dissolved in ether, and 4N hydrochloric acid/ethyl acetate was added. The precipitated crystals were collected by filtration to give the title compound (280 mg) as white crystals.

Provenance & Evidence