4-Aminopyridine → HCID 67397782, compound

Participants

Reaction Steps

A compound obtained using 2-{[4-(2-hydroxyethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid tert-butyl ester synthesized in Example 4 and 4-aminopyridine as starting materials and by operations similar to those of Reference Example 14, Example 286-1, Example 286-2 and Example 265-2 was dissolved in dioxane, an excess amount of 4 mol/L hydrochloric acid-dioxane was added, and the mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (elution solvent; chloroform:methanol=10:1) to give the title compound as an amorphous solid.

Provenance & Evidence