2,6-Dichlorobenzothiazole → HCID 67398460, compound

HRID 914439Notes

Reaction equation

HRID 914439 reaction equation
C([O:5][C:6](=[O:26])[C:7]([S:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][CH2:17][NH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[N:15]=1)([CH3:9])[CH3:8])(C)(C)C.[Cl:27][C:28]1[S:29][C:30]2[CH:36]=[C:35]([Cl:37])[CH:34]=[CH:33][C:31]=2[N:32]=1.Cl.C(OCC)(=O)C>C(O)=O>[ClH:27].[Cl:37][C:35]1[CH:34]=[CH:33][C:31]2[N:32]=[C:28]([N:18]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH2:17][CH2:16][C:14]3[N:15]=[C:11]([S:10][C:7]([CH3:8])([CH3:9])[C:6]([OH:5])=[O:26])[S:12][CH:13]=3)[S:29][C:30]=2[CH:36]=1

Participants

5

Reactant 3

HCID 771762,6-DichlorobenzothiazoleHCID 21866389Hydrogen chloride-ethyl acetateHCID 597593122-({4-[2-(Heptylamino)ethyl]-1,3-thiazol-2-yl}thio)-2-methylpropionic acid tert-butyl ester

Product 1

HCID 67398460HCID 67398460, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A compound obtained using 2-({4-[2-(heptylamino)ethyl]-1,3-thiazol-2-yl}thio)-2-methylpropionic acid tert-butyl ester synthesized in Example 303-2 and 2,6-dichloro-1,3-benzothiazole as starting materials and by an operation similar to that of Example 303-3 was treated with formic acid and 4 mol/L hydrochloric acid-ethyl acetate, and the mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated under reduced pressure to give the title compound.

Workup

  1. customA compound obtained
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f98dce49b2ad4569b21d03520b8c1bf9
Source dataset
uspto-grants-2011_09
Patent number
US08026370B2

Reaction notes

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