5-Methyl-1-hexanol → HCID 67398639, compound

HRID 914465Notes

Reaction equation

HRID 914465 reaction equation
I[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]([CH3:8])[CH3:7].C([O:13][C:14](=[O:35])[C:15]([S:18][C:19]1[S:20][CH:21]=[C:22]([CH2:24][CH2:25][NH:26][C:27]2[N:32]=[CH:31][C:30]([CH2:33][CH3:34])=[CH:29][N:28]=2)[N:23]=1)([CH3:17])[CH3:16])(C)(C)C.CC(C)CCCCO.[BrH:44].C(O)(=O)C>C(OCC)C>[BrH:44].[CH2:33]([C:30]1[CH:29]=[N:28][C:27]([N:26]([CH2:2][CH2:3][CH2:4][CH2:5][CH:6]([CH3:8])[CH3:7])[CH2:25][CH2:24][C:22]2[N:23]=[C:19]([S:18][C:15]([CH3:16])([CH3:17])[C:14]([OH:35])=[O:13])[S:20][CH:21]=2)=[N:32][CH:31]=1)[CH3:34]

Participants

6

Reactant 4

HCID 123315-Methyl-1-hexanolHCID 11806363HCID 11806363, compoundHCID 21893785Acetic Acid Mixture with Hydrobromic AcidHCID 597588712-[(4-{2-[(5-Ethylpyrimidin-2-yl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester

Product 1

HCID 67398639HCID 67398639, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A compound obtained using 1-iodo-5-methylhexane, which is synthesized using 2-[(4-{2-[(5-ethylpyrimidin-2-yl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester synthesized in Example 265-1 and 5-methylhexanol as starting materials and in reference to non-patent reference [Tetrahedron, 38, 11461 (1998)], and by an operation similar to that of Example 326, was dissolved in diethyl ether, and reacted with 30% hydrobromic acid-acetic acid to give the title compound.

Workup

  1. customA compound obtained
  2. customis synthesized

Sources & evidence

ORD record
ord-efd71c89ae354307aa9eca877666f008
Source dataset
uspto-grants-2011_09
Patent number
US08026370B2

Reaction notes

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