Isooctan-1-ol → HCID 67399319, compound

HRID 914466Notes

Reaction equation

HRID 914466 reaction equation
[CH3:1][CH:2]([CH3:9])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]I.C([O:14][C:15](=[O:36])[C:16]([S:19][C:20]1[S:21][CH:22]=[C:23]([CH2:25][CH2:26][NH:27][C:28]2[N:33]=[CH:32][C:31]([CH2:34][CH3:35])=[CH:30][N:29]=2)[N:24]=1)([CH3:18])[CH3:17])(C)(C)C.CC(C)CCCCCO.[BrH:46].C(O)(=O)C>C(OCC)C>[BrH:46].[CH2:34]([C:31]1[CH:30]=[N:29][C:28]([N:27]([CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH:2]([CH3:9])[CH3:1])[CH2:26][CH2:25][C:23]2[N:24]=[C:20]([S:19][C:16]([CH3:17])([CH3:18])[C:15]([OH:36])=[O:14])[S:21][CH:22]=2)=[N:33][CH:32]=1)[CH3:35]

Participants

6

Reactant 4

HCID 15450Isooctan-1-olHCID 10879225HCID 10879225, compoundHCID 21893785Acetic Acid Mixture with Hydrobromic AcidHCID 597588712-[(4-{2-[(5-Ethylpyrimidin-2-yl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester

Product 1

HCID 67399319HCID 67399319, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A compound obtained using 6-methyl-1-iodoheptane, which is synthesized using 2-[(4-{2-[(5-ethylpyrimidin-2-yl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester synthesized in Example 265-1 and 6-methylheptanol as starting materials and in reference to non-patent reference [Tetrahedron, 38, 11461 (1998)], and by an operation similar to that of Example 326, was dissolved in diethyl ether, and reacted with 30% hydrobromic acid-acetic acid to give the title compound.

Workup

  1. customA compound obtained
  2. customis synthesized

Sources & evidence

ORD record
ord-e5b08b3d79bc4149b584f4175d308e44
Source dataset
uspto-grants-2011_09
Patent number
US08026370B2

Reaction notes

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