反应详情

4-Fluorobenzamide (10.0 g) and 1,3-dichloroacetone (9.5 g) were dissolved in ethanol (100 mL), and the mixture was refluxed for 8 hr. After cooling, the reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (elution solvent; hexane:ethyl acetate=10:1 to 7:1) to give the title compound (4.3 g) as a white solid.

1. temperaturethe mixture was refluxed for 8 hr
2. temperatureAfter cooling
3. concentrationthe reaction mixture was concentrated under reduced pressure
4. customthe residue was purified by silica gel chromatography (elution solvent; hexane:ethyl acetate=10:1 to 7:1)