反应详情

Lithium aluminum hydride (1.16 g) was suspended in diethyl ether (100 mL), a solution (50 mL) of 4-propylbenzoic acid (5.0 g) in diethyl ether was added under ice-cooling, and the mixture was heated under reflux for 2.5 hr. The reaction mixture was ice-cooled, and water (3.0 mL) and aqueous sodium hydroxide solution (1 mol/L, 12 mL) were successively added dropwise. After warming to room temperature, the mixture was stirred for 30 min. The reaction mixture was directly filtered through celite, and the filtrate was evaporated under reduced pressure to give the title compound (4.9 g) as a colorless oil.

1. temperaturecooling
2. temperaturethe mixture was heated
3. temperatureunder reflux for 2.5 hr
4. temperaturecooled
5. filtrationThe reaction mixture was directly filtered through celite
6. customthe filtrate was evaporated under reduced pressure