Dichloromethane → HCID 67398538, compound

Participants

Reaction Steps

2-[(4-{2-[(5-Ethylpyrimidin-2-yl)(4-pyrazin-2-ylbenzyl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester (180 mg) obtained in Example 403-1 was dissolved in dichloromethane (6 mL), trifluoroacetic acid (2 mL) was added, and the mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (elution solvent; dichloromethane:methanol=10:1). The obtained compound was dissolved in diethyl ether (5 mL), hydrochloric acid-ethyl acetate (4 mol/L, 1 mL) was added, and the mixture was stirred at room temperature for 1 hr. The precipitated solid was collected by filtration to give the title compound (140 mg) as a white solid.

Provenance & Evidence