Diisopropylethylamine → 2-[(4-{[(5-Ethylpyrimidin-2-yl)amino]methyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester

Participants

Reaction Conditions

Reaction Steps

N,N-Diisopropylethylamine (2.24 g) was added to 2-{[4-(aminomethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid tert-butyl ester (5.0 g) synthesized in Example 13 and 2-chloro-5-ethylpyrimidine (2.47 g), and the mixture was stirred at 130° C. for 8 hr. The reaction mixture was directly purified by silica gel chromatography (elution solvent; hexane:ethyl acetate=1:1) to give the title compound (5.0 g) as a slightly yellow oil.

Provenance & Evidence