Piperidine → HCID 59758966, compound

Participants

Reaction Steps

To a solution of 2-{[4-(2-{3-[(9H-fluorene-9-ylmethoxy)carbonyl]-1-heptylthioureido}ethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid tert-butyl ester (3.1 g) synthesized in Example 629-1 in methanol (40 mL) was added piperidine (20 mL), and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and subjected to silica gel chromatography (elution solvent; hexane:ethyl acetate=2:1) to give the title compound (2.0 g) as a colorless oil.

Provenance & Evidence