tert-Butyl 2-bromopropanoate → HCID 67398041, compound

HRID 914525Notes

Reaction equation

HRID 914525 reaction equation
[CH2:1]([O:3][C:4](=[O:12])[CH2:5][C:6]1[N:7]=[C:8]([SH:11])[S:9][CH:10]=1)[CH3:2].[C:13]([O:17][C:18](=[O:22])[CH:19](Br)[CH3:20])([CH3:16])([CH3:15])[CH3:14]>>[C:13]([O:17][C:18](=[O:22])[CH:19]([S:11][C:8]1[S:9][CH:10]=[C:6]([CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:12])[N:7]=1)[CH3:20])([CH3:16])([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 545327tert-Butyl 2-bromopropanoateHCID 178470768HCID 178470768, compound

Product 1

HCID 67398041HCID 67398041, compound

Procedure

The title compound was obtained by an operation similar to that of Example 2 and using (2-mercapto-1,3-thiazol-4-yl)acetic acid ethyl ester synthesized in Example 1 and 2-bromopropionic acid tert-butyl ester to give 2-{[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]thio}propionic acid tert-butyl ester, followed by sequential operations similar to those of Examples 3, 4 and 34.

Sources & evidence

ORD record
ord-fb94bde60863450da3a11d4d31e9a9be
Source dataset
uspto-grants-2011_09
Patent number
US08026370B2

Reaction notes

Loading…