Pyridine → Octadecylamine

Participants

Reaction Steps

A mixture of 31 g of the white solid obtained in Intermediate Preparation Example 4, 27 g of n-octadecylamine, 130 g of methyl ethyl ketone and 1.0 g of pyridine was heated at a temperature of 70° C. and reacted with stirring for 10 hours. After cooling, the reaction mixture was added in 1.0 L of methanol with stirring over 15 minutes, and the mixture was further stirred for one hour. A deposited solid was collected by filtration and dried in vacuo to obtain 48 g of a pale whitish yellow solid. The resulting compound had a molecular weight measured by high performance liquid chromatography of 15,000.

Provenance & Evidence