Pyridine → Octylamine
Reaction equation
[CH2:1]([C:3](C)=O)[CH3:2].[N:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[CH2:11]([NH2:6])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:2][CH2:1][CH3:3]Participants
3
Reactant 2
Product 1
Procedure
A mixture of 20.4 g of the white solid obtained in Intermediate Preparation Example 8, 6.4 g of n-octylamine, 80 g of methyl ethyl ketone and 0.8 g of pyridine was heated at a temperature of 70° C. and reacted with stirring for 10 hours. After cooling, the reaction mixture was added in 800 mL of methanol with stirring over 15 minutes, and the mixture was further stirred for one hour. A deposited solid was collected by filtration and dried in vacuo to obtain 28 g of a pale whitish yellow solid. The resulting compound had a molecular weight measured by high-performance liquid chromatography of 15,000.
Sources & evidence
- ORD record
- ord-c1f9a15b32334a51ae7f77dfc7d16be8
- Source dataset
- uspto-grants-2007_09
- Patent number
- US07264344B2
Reaction notes
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