反应详情

Ethanol (70 mL) was added with 12-bromododecanoic acid (4.8 g) and 2,4,6-triiodophenol (9.1 g) and the mixture was refluxed for dissolution. The solution was added with potassium hydroxide (2.2 g) and stirred for 12 hours. The precipitates obtained were separated by filtration, washed with ethanol and added with chloroform and 1 N hydrochloric acid to conduct extraction with chloroform twice. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was removed, and the resulting residue was purified by silica gel column chromatography to obtain 12-(2,4,6-triiodophenoxy)dodecanoic acid (7.0 g, yield: 60%). In the same manner as the synthetic method of 12-(2,4,6-triiodophenoxy)dodecanoic acid, 16-(2,4,6-triiodophenoxy)hexadecanoic acid was synthesized from 16-bromohexadecanoic acid.

1. temperaturethe mixture was refluxed for dissolution
2. customThe precipitates obtained
3. customwere separated by filtration
4. washwashed with ethanol
5. additionadded with chloroform and 1 N hydrochloric acid
6. extractionextraction with chloroform twice
7. dry with materialAfter the organic layer was dried over anhydrous magnesium sulfate
8. customthe solvent was removed
9. customthe resulting residue was purified by silica gel column chromatography