反应详情

Ethanol (95%, 30 mL) was added with of ethyl 7-(2,4,6-triiodophenoxy)heptanoate (4.0 g) and the mixture was refluxed for dissolution, and the solution was added with sodium hydroxide (0.5 g) and further refluxed for 1.5 hours. The crystals obtained were separated by filtration, washed with ethanol and added with dichloromethane and 1 N hydrochloric acid to conduct extraction twice with dichloromethane. The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was removed. The resulting residue was purified by silica gel column chromatography to obtain 7-(2,4,6-triiodophenoxy)heptanoic acid (3.4 g, yield: 90%).

1. temperaturethe mixture was refluxed for dissolution
2. temperaturefurther refluxed for 1.5 hours
3. customThe crystals obtained
4. customwere separated by filtration
5. washwashed with ethanol
6. additionadded with dichloromethane and 1 N hydrochloric acid
7. extractionextraction twice with dichloromethane
8. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
9. customthe solvent was removed
10. customThe resulting residue was purified by silica gel column chromatography