HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 1-(6-(4-Pyrazolyl)-2-benzothiazolyl)-3-ethylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| Reactant | 1-(6-Bromo-2-benzothiazolyl)-3-ethylurea | HCID 21985564 | — |
| Reactant | 1-(6-(3-Aminophenyl)-2-benzothiazolyl)-3-ethylurea | HCID 21985575 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 1-(6-(4-Pyrazolyl)-2-benzothiazolyl)-3-ethylurea | HCID 21985578 | 30% |
Reaction Steps
Similar to the synthesis of 1-(6-(3-aminophenyl)-2-benzothiazolyl)-3-ethylurea, a mixture of 4-pyrazolylboronic pinacolate, 1-(6-bromo-2-benzothiazolyl)-3-ethylurea, sodium carbonate, and Pd(PPh3)4 in DMF/water mixed solvent was reacted to give the desired compound 0.543 g (30%). LC/MS 288.2 (M+1); LC retention time 2.61 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07091227B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-a5f3ce06d6ac4f33ac47c498605c9889 |
| Source note | uspto-grants-2006_08 |