Ether hydrochloride → 3-(6-Nitro-3-pyridinyl)-3,8-diazabicyclo[3.2.1]octane dihydrochloride

Participants

Reaction Steps

The product from Example 10A was treated with 1M HCl/ether to provide the title compound (55% yield). 1H NMR (DMSO-d6, 300 MHz) δ 1.9-2.0 (m, 4H), 3.4-3.5 (m, 2H), 4.00 (d, J=11 Hz, 2H), 4.20 (br s, 2H), 7.5-7.6 (m, 1H), 8.2-8.3 (m, 2H), 9.6-9.7 (br s, 3H, exchangeable).

Provenance & Evidence