Ether hydrochloride → 3-(6-Amino-3-pyridinyl)-3,8-diazabicyclo[3.2.1]octane trihydrochloride

Participants

Reaction Steps

The product from Example 11A was treated with 1M HCl/ether to provide the title compound (72% yield). 1H NMR (DMSO-d6, 300 MHz) δ 2.00 (s, 4H), 3.2 (d, J=11 Hz, 2H), 3.4 (s, J=11 Hz, 2H), 4.20 (br s, 2H), 5.80 (s, 2H, exchangeable), 7.00, (d, J=8.5 Hz, 1H), 7.40 (br s, 1H), 7.80 (br s, 2H, exchangeable), 7.9-8.0 (m, 1H), 9.10 (br s, 2H, exchangeable).

Provenance & Evidence