(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane → HCID 16748924, compound

HRID 914750Notes

Reaction equation

HRID 914750 reaction equation
[C@H:1]12[CH2:7][C@H:4]([NH:5][CH2:6]1)[CH2:3][N:2]2[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].[CH2:15]([O:22][C:23]1[CH:24]=[N:25][CH:26]=[C:27](Br)[CH:28]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:15]([O:22][C:23]1[CH:28]=[C:27]([N:5]2[CH2:6][C@@H:1]3[CH2:7][C@H:4]2[CH2:3][N:2]3[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH:26]=[N:25][CH:24]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 11521263(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptaneHCID 153891983-(Benzyloxy)-5-bromopyridine

Product 1

HCID 16748924HCID 16748924, compound

Procedure

tert-Butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate, prepared as described in (J. Med. Chem., (1988) 31, 1598-1611) and 3-(benzyloxy)-5-bromopyridine, prepared as described in (U.S. Pat. No. 5,733,912) were coupled according to the procedure described in Example 1A to provide the title compound. MS (DCI/NH3) m/z 382 (M+H)+.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-a74dc6609c93482e902e194013ebe910
Source dataset
uspto-grants-2007_09
Patent number
US07265115B2

Reaction notes

Loading…