5-Bromo-2-methylpyridine → HCID 16748712, compound

HRID 914751Notes

Reaction equation

HRID 914751 reaction equation
[C@H:1]12[CH2:7][C@H:4]([NH:5][CH2:6]1)[CH2:3][N:2]2[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].Br[C:16]1[CH:17]=[CH:18][C:19]([CH3:22])=[N:20][CH:21]=1>>[CH3:22][C:19]1[N:20]=[CH:21][C:16]([N:5]2[CH2:6][C@@H:1]3[CH2:7][C@H:4]2[CH2:3][N:2]3[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 12010205-Bromo-2-methylpyridineHCID 11521263(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

Product 1

HCID 16748712HCID 16748712, compound

Procedure

tert-Butyl (1S,4S)-2,5-diazabicyclo [2.2.1]heptane-2-carboxylate, prepared as described in (J. Med. Chem., (1988) 31, 1598-1611), and 5-bromo-2-methyl-pyridine (purchased from Emka Chemie) were coupled according to the procedure described in Example 1A to provide the title product. MS (DCI/NH3) m/z 290 (M+H)+.

Sources & evidence

ORD record
ord-407e7478eac443f6a35aef2bbdef44f6
Source dataset
uspto-grants-2007_09
Patent number
US07265115B2

Reaction notes

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