3,5-Dibromopyridine → HCID 12016224, compound

HRID 914754Notes

Reaction equation

HRID 914754 reaction equation
[C@H:1]12[CH2:7][C@H:4]([NH:5][CH2:6]1)[CH2:3][N:2]2[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].[Br:15][C:16]1[CH:17]=[N:18][CH:19]=[C:20](Br)[CH:21]=1>>[Br:15][C:16]1[CH:21]=[C:20]([N:5]2[CH2:6][C@@H:1]3[CH2:7][C@H:4]2[CH2:3][N:2]3[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH:19]=[N:18][CH:17]=1

Participants

3

Reactant 2

HCID 693693,5-DibromopyridineHCID 11521263(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

Product 1

HCID 12016224HCID 12016224, compound

Procedure

tert-Butyl (1S,4S)-2,5-diazabicyclo [2.2.1]heptane-2-carboxylate, prepared as described in (J. Med. Chem., (1988) 31, 1598-1611), and 3,5-dibromopyridine (purchased from Avocado Research Chemicals, Ltd.) were coupled according to the procedure described in Example 1A to provide the title compound. MS (DCI/NH3) m/z 354 (M+H)+.

Sources & evidence

ORD record
ord-c74120abfe154132b2c9bcd0fa341c4e
Source dataset
uspto-grants-2007_09
Patent number
US07265115B2

Reaction notes

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