3-Bromo-5-methoxypyridine → HCID 16749032, compound

HRID 914757Notes

Reaction equation

HRID 914757 reaction equation
[C@H:1]12[CH2:7][C@H:4]([NH:5][CH2:6]1)[CH2:3][N:2]2[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].Br[C:16]1[CH:17]=[N:18][CH:19]=[C:20]([O:22][CH3:23])[CH:21]=1>>[CH3:23][O:22][C:20]1[CH:21]=[C:16]([N:5]2[CH2:6][C@@H:1]3[CH2:7][C@H:4]2[CH2:3][N:2]3[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH:17]=[N:18][CH:19]=1

Participants

3

Reactant 2

HCID 8171633-Bromo-5-methoxypyridineHCID 11521263(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

Product 1

HCID 16749032HCID 16749032, compound

Procedure

tert-Butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate, prepared as described in (J. Med. Chem., (1988) 31, 1598-1611), and the product from Example 43A were coupled according to the procedure described in Example 1A to provide the title compound. MS (DCI/NH3) m/z 306 (M+H)+.

Sources & evidence

ORD record
ord-91c0af70509a4202b4c75580dbe65ed4
Source dataset
uspto-grants-2007_09
Patent number
US07265115B2

Reaction notes

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