HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → HCID 87214300, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-{4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}propan-2-ol | HCID 22337996 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 87214300 | HCID 87214300 | 92% |
Reaction Steps
A mixture of Example 1 (311 mg, 1 mmol), (2S)-(+)-glycidyl nosylate (311 mg, 1.2 mmol), and K2CO3 (200 mg, 1.45 mmol) in DMF (3 mL) was stirred at RT for 4 hr. The mixture was diluted with ethyl acetate and the solids were filtered. The filtrate was washed with brine, dried, and concentrated. The residue was purified by flash column chromatography (silica gel, 50% ethyl acetate in hexanes) to afford the title compound (340 mg, 92% yield). LC/MS; (M+H)+=369.1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07265113B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-c8dedf8352aa4c2f91991e45493b68b3 |
| Source note | uspto-grants-2007_09 |