HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 1-(6-(4-Chlorophenyl)-2-benzothiazolyl)-3-ethylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | p-Chlorophenylboric acid | HCID 17810664 | — |
| Reactant | 1-(6-Bromo-2-benzothiazolyl)-3-ethylurea | HCID 21985564 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| Product | 1-(6-(4-Chlorophenyl)-2-benzothiazolyl)-3-ethylurea | HCID 21985618 | 18% |
Reaction Steps
Similar to the synthesis of 1-(6-(4-pyrrazolyl)-2-benzothiazolyl)-3-ethylurea, a mixture of 1-(6-bromo-2-benzothiazolyl)-3-ethylurea, 4-chlorophenylboric acid, sodium bicarbonate, and Pd(PPh3)4 in DMF/water mixed solvent (5/1) was reacted to give the desired compound 0.020 g (18%). LC/MS 330 (M−1); LC retention time 2.70 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07091227B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-60da8dac3f014ed1b9238d03474e7f55 |
| Source note | uspto-grants-2006_08 |