HCID 22248068, compound → HCID 22248264, compound

HRID 914813Notes

Reaction equation

HRID 914813 reaction equation
[CH2:1]([N:8]1[CH2:13][CH:12]=[C:11]([C:14](=[O:22])[CH2:15][C:16]2[CH:20]=[CH:19][S:18][C:17]=2[F:21])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14](=[O:22])[CH2:15][C:16]2[CH:20]=[CH:19][S:18][C:17]=2[F:21])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 22248068HCID 22248068, compound

Product 1

HCID 22248264HCID 22248264, compoundYield 81.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

After dissolving 292 mg of 1-benzyl-4-[2-(2-fluoro-3-thienyl)acetyl]-1,2,3,6-tetrahydropyridine in 10 ml of ethanol, 0.1 g of 20% palladium-hydroxide-carbon (hydrous) was added and the mixture was stirred for 1 hour at room temperature under a hydrogen atmosphere (1 atm). The reaction mixture was filtered and the filtrate was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (solvent: n-hexane/ethyl acetate) to obtain the title compound (239 mg, 81% yield).

Workup

  1. additionwas added
  2. filtrationThe reaction mixture was filtered
  3. distillationthe filtrate was distilled off under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (solvent: n-hexane/ethyl acetate)

Sources & evidence

ORD record
ord-2efaf617dfc84c0dac06d53fe6fbac03
Source dataset
uspto-grants-2007_09
Patent number
US07265108B2

Reaction notes

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