HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 5-(4-(2-Fluorophenoxymethyl)piperidino]methyl-2,4-dihydro-[1,2,4]triazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-((2-Fluorophenoxy)methyl)piperidine hydrochloride | HCID 17178050 | — |
| Reactant | 3H-1,2,4-Triazol-3-one, 5-(chloromethyl)-1,2-dihydro- | HCID 135546685 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-(4-(2-Fluorophenoxymethyl)piperidino]methyl-2,4-dihydro-[1,2,4]triazol-3-one | HCID 135593011 | 21% |
Reaction Steps
After adding 150 mg of 5-chloromethyl-2,4-dihydro-[1,2,4]triazol-3-one, 331 mg of 4-(2-fluorophenoxymethyl)piperidine hydrochloride and 180 mg of anhydrous potassium carbonate to acetonitrile, the mixture was stirred overnight at room temperature. Water and ethyl acetate were added to the reaction mixture and the insoluble portion was filtered out to obtain the title compound (70 mg, 21% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07265108B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-ecf08859a8864be1b28c37065c2a474d |
| Source note | uspto-grants-2007_09 |