反应详情

A solution of rac-1-benzyl-4-(2-nitro-1-phenyl-ethyl)-piperidine-4-carboxylic acid ethyl ester (3.18 g, 8 mmol) in dry EtOH (240 mL) was hydrogenated in the presence of Ra—Ni (3 g) at 60 bar at 55° C. for 3 h. After cooling and decompression of the reaction vessel, the mixture was filtered over celite and the filtrate evaporated to leave the title compound (2.9 g, 99%) as a clear oil. MS: m/e=367.4 (M+H).

1. temperatureAfter cooling
2. filtrationdecompression of the reaction vessel, the mixture was filtered over celite
3. customthe filtrate evaporated