反应详情

To a solution of 2-(3-nitrobenzenesulfonyl)ethanol (101) (5.0 g, 21.6 mmol) in dichloromethane (31.5 mL) and pyridine (7 mL) was added methanesulfonyl chloride (4.9 g, 43 mmol). The mixture was stirred at room temperature overnight before it was partitioned between dichloromethane (200 mL) and 0.5 N HCl (200 mL). The organic layer was dried over MgSO4 and concentrated on a rotavap to give 102 (4.78 g, 71%).

1. customwas partitioned between dichloromethane (200 mL) and 0.5 N HCl (200 mL)
2. dry with materialThe organic layer was dried over MgSO4
3. concentrationconcentrated on a rotavap