1-Ethylpiperidin-3-one hydrochloride → HCID 19694168, compound

HRID 915Notes

Reaction equation

HRID 915 reaction equation
[CH2:1]([N:8]1[C:16]2[CH:15]=[CH:14][N:13]=[C:12]([Cl:17])[C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]([N:20]1[CH2:25][CH2:24][CH2:23][C:22](=[O:26])[CH2:21]1)[CH3:19]>>[CH2:1]([N:8]1[C:16]2[CH:15]=[CH:14][N:13]=[C:12]([Cl:17])[C:11]=2[N:10]=[C:9]1[C:22]1([OH:26])[CH2:23][CH2:24][CH2:25][N:20]([CH2:18][CH3:19])[CH2:21]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 4334391-Ethylpiperidin-3-one hydrochlorideHCID 141991521-Benzyl-4-chloro-1H-imidazo[4,5-c]pyridine

Product 1

HCID 19694168HCID 19694168, compound

Procedure

Following the procedure of Example 13 and using 1-benzyl-4-chloro-1H-imidazo[4,5-c]pyridine (0.60 g, 2.5 mmol) and (0.36 g, 2.8 mmol) of N-ethyl-3-piperidone gave the free base of the title compound which was purified by flash chromatography on silica gel eluting with EtOAc to give, after preparation of the salt, the dihydrochloride, 0.59 hydrate as an amorphous solid, 0.30 g (26%):

Sources & evidence

ORD record
ord-ba5fcf5d0a3744acbef08bc1f8e5f3b4
Source dataset
uspto-grants-1998_03
Patent number
US05723468

Reaction notes

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