Hydrochloric Acid → 6-(1-amino-2-oxo-2-phenylethyl)-2-isopropyl-3(2H)-pyridazinone hydrochloride

Beteiligte Stoffe

Reaktionsschritte

A solution of N-[1-(1-isopropyl-6-oxo-1,6-dihydro-3-pyridazinyl)-2-oxo-2-phenylethyl]acetamide (1.00 g) in 10% hydrogen chloride solution of MeOH (10 ml) was refluxed for 24 hours. After cooling, a precipitate was collected by filtration to give 6-(1-amino-2-oxo-2-phenylethyl)-2-isopropyl-3(2H)-pyridazinone hydrochloride as a solid (534 mg). A filtrate was concentrated under reduced pressure, triturated with IPE and collected by filtration to give the same compound as a solid (333 mg).

Herkunft & Nachweise