Acetic Acid → HCID 69332645, compound

Participants

Reaction Conditions

Reaction Steps

A solution of methyl [1-(1-isopropyl-6-oxo-1,6-dihydro-3-pyridazinyl)-2-oxo-2-phenylethyl]carbamate (2.46 g) in DMF (10 ml) was added to a suspension of NaH (60% dispersion in mineral oil) (314 mg) in DMF (15 ml) and the mixture was heated at 70-75° C. for 3 hours. A mixture of AcOH (0.5 ml) and water (75 ml) was added to the mixture to give a precipitate. The precipitate was collected by filtration and dried under reduced pressure to give 2-isopropyl-6-(2-oxo-5-phenyl-2,3-dihydro-oxazol-4-yl)-3(2H)-pyridazinone as a solid (1.56 g).

Provenance & Evidence