反应详情

A suspension of 3-amino-6-(1-isopropyl-6-oxo-1,6-dihydro-3-pyridazinyl)-5-phenyl-2-pyrazinecarboxylic acid (250 mg) in o-dichlorobenzene (1.25 ml) was refluxed for 2 hours. After cooling, IPE (2.5 ml) was added to the reaction mixture to yield a precipitate. The precipitate was collected by filtration to give 6-(5-amino-3-phenyl-2-pyrazinyl)-2-isopropyl-3(2H)-pyridazinone as a solid (205 mg).

1. temperaturewas refluxed for 2 hours
2. temperatureAfter cooling
3. additionIPE (2.5 ml) was added to the reaction mixture
4. customto yield a precipitate
5. filtrationThe precipitate was collected by filtration