m-Chloroperbenzoic acid → HCID 69331470, compound

Participants

Reaction Conditions

Reaction Steps

Under ice-cooling, m-chloroperbenzoic acid (70-75% purity) (530 mg) was added to a mixture of 6-[5-amino-6-(methylsulfinyl)-3-phenyl-2-pyrazinyl]-2-isopropyl-3(2H)-pyridazinone (750 mg) in CH2Cl2 (7.5 ml). The mixture was stirred at 25-30° C. for 5 hours, washed with saturated aq. sodium thiosulfate, saturated aq. NaHCO3 and brine, dried over MgSO4 and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography on silica gel eluting with a mixture of n-hexane and EtOAc (30:70 v/v) to give 6-[5-amino-6-(methylsulfonyl)-3-phenyl-2-pyrazinyl]-2-isopropyl-3(2H)-pyridazinone as a solid (524 mg).

Provenance & Evidence