Hydrochloric Acid → HCID 11558386, compound

Participants

Reaction Steps

A suspension of 2-ethyl-6-{5-[(4-methoxybenzyl)amino]-3-phenyl-2-pyrazinyl}-3(2H)-pyridazinone (500 mg) in a mixture of conc. HCl (1.5 ml) and toluene (0.5 ml) was refluxed for 4 hours. After removal of an organic layer, an aqueous layer was adjusted to pH 4 with 6N aq. NaOH under ice-cooling. The precipitate was purified by column chromatography on silica gel eluting with a mixture of n-hexane and EtOAc (20:80 v/v) to give 6-(5-amino-3-phenyl-2-pyrazinyl)-2-ethyl-3(2H)-pyridazinone (213 mg).

Provenance & Evidence