Water → HCID 69333137, compound

Participants

Reaction Steps

In the presence of copper(I) iodide (4.3 mg) and dichlorobis(triphenylphosphine)palladium(II) (15.7 mg), triethylamine (0.0685 ml) was dropwise added to a mixture of 6-(5-amino-6-bromo-3-phenyl-2-pyrazinyl)-2-methyl-3(2H)-pyridazinone (150 mg) and ethynylbenzene (0.0054 ml) in DMF (1.5 ml) at 75-80° C. The mixture was stirred at the same temperature for 2 hours. To the reaction mixture, water was added to give a solid. The solid was purified by column chromatography on silica gel eluting with a mixture of n-hexane and EtOAc (40:60 v/v) to give a solid. The solid was suspended in acetone to give 6-[5-amino-3-phenyl-6-(phenylethynyl)-2-pyrazinyl]-2-methyl-3(2H)-pyridazinone (96 mg).

Provenance & Evidence