Hydrochloric Acid → HCID 69331934, compound

Participants

Reaction Steps

Under ice-cooling, sodium borohydride (30.7 mg) was added to a solution of 4-[3-amino-6-(1-isopropyl-6-oxo-1,6-dihydro-3-pyridazinyl)-5-phenyl-2-pyrazinyl]-1-methylpyridinium iodide (142 mg) in MeOH (4.26 ml) and the mixture was stirred at the same temperature for 30 minutes. After addition of 1N HCl (0.6 ml), MeOH was evaporated under reduced pressure to give a residue. The residue was dissolved in CHCl3, dried over MgSO4 and purified by column chromatography on silica gel eluting with a mixture of MeOH and EtOAc (5:95 v/v) to give a solid. The solid was suspended in acetone and collected by filtration to give 6-[5-amino-6-(1-methyl-1,2,3,6-tetrahydro-4-pyridyl)-3-phenyl-2-pyrazinyl]-2-isopropyl-3(2H)-pyridazinone (15 mg).

Provenance & Evidence