Acetone → HCID 69331883, compound

Participants

Reaction Conditions

Reaction Steps

In the presence of palladium acetate (14.6 mg) and triphenylphosphine (34.0 mg), diisopropylethylamine (0.687 ml) was added to a mixture of 6-(5-amino-6-bromo-3-phenyl-2-pyrazinyl)-2-isopropyl-3(2H)-pyridazinone (501 mg) in DMF (2 ml) and the mixture was heated at 100-105° C. for 20 hours. After addition of water, a precipitate was collected by filtration and purified by column chromatography on silica gel eluting with a mixture of n-hexane and EtOAc (50:50 v/v) to give a solid. The solid was suspended in acetone and collected by filtration to give ethyl 3-[3-amino-6-(1-isopropyl-6-oxo-1,6-dihydro-3-pyridazinyl)-5-phenyl-2-pyrazinyl]acrylate (95 mg).

Provenance & Evidence