Water → HCID 69331848, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-(5-amino-6-bromo-3-phenyl-2-pyrazinyl)-2-isopropyl-3(2H)-pyridazinone (100 mg) and benzylamine (0.085 ml) in DMA (0.2 ml) was heated at 120-125° C. for 50 hours. After addition of water (4 ml), an aqueous layer was removed by decantation to give a residue. The residue was dissolved in CHCl3, dried over MgSO4, concentrated under reduced pressure and purified by preparative TLC on silica gel (CHCl3 only). A less polar zone was gave 6-[5-amino-6-(dimethylamino)-3-phenyl-2-pyrazinyl]-2-isopropyl-3(2H)-pyridazinone as a solid (18 mg) and a more polar zone was gave 6-[5-amino-6-(benzylamino)-3-phenyl-2-pyrazinyl]-2-isopropyl-3(2H)-pyridazinone as a solid (67 mg).

Provenance & Evidence